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Posts Tagged ‘pbc’

Age, not sex affects UDCA response in patients with PBC

Primary Biliary Cholangitis Older and increasing age among patients with primary biliary cholangitis correlated with a better response to ursodeoxycholic acid treatment and lower rates of liver transplantation and mortality compared with younger age, whereas sex did not affect outcomes, according to a recently published study. “Our data suggests that younger patients should be monitored…

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‘Deranged liver blood tests’ – diagnosing PBC

‘Deranged liver blood tests’ – diagnosing primary biliary cholangitis 22 October 2018 In the first of a new gastroenterology clinic series, Dr Amine Benmassaoud and Dr Emmanuel Tsochatzis discuss a case of unusual liver bloods Case A 54 year old lady with hypothyroidism on levothyroxine, osteopenia on calcium and vitamin D, and dry eyes on…

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What Is Primary biliary cholangitis?

Primary biliary cholangitis Bile duct damage Primary biliary cholangitis, previously called primary biliary cirrhosis, is a chronic disease in which the bile ducts in your liver are slowly destroyed. Bile is a fluid made in your liver. It aids with digestion and helps your body get rid of cholesterol, toxins and worn-out red blood cells.…

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New Self-Care App for Primary Biliary Cholangitis (PBC)

New Self-Care App to Support Self-Management for Primary Biliary Cholangitis (PBC) The PBC Health Storylines Mobile App From Self Care Catalysts Was Developed in Collaboration With Patients, and in Partnership With the Canadian PBC Society TORONTO, ON–(Marketwired – September 09, 2016) – To celebrate International PBC Day on September 11, 2016, Self Care Catalysts —…

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Obeticholic acid reduces ALP and bilirubin in primary biliary cholangitis

Obeticholic acid reduced alkaline phosphatase and bilirubin levels in patients with primary biliary cholangitis, according to a phase 3 study published in The New England Journal of Medicine. However, patients taking the drug were more likely to experience pruritis. “The approval of obeticholic acid for primary biliary cholangitis gives us the first new drug for…

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UDCA fails to improve mortality in primary biliary cholangitis

April 13, 2016 BARCELONA — The use of ursodeoxycholic acid for primary biliary cholangitis failed to reduce all-cause mortality, according to results of a systematic review presented at the International Liver Congress 2016. “Based on current evidence, the treatment of primary biliary cholangitis with ursodeoxycholic acid can neither be supported nor rejected,” Jelena Nincevic, MD,…

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Environmental Factors Tied to PBC – Acetaminophen specifically.

Environmental Factors Tied to PBC Loss of tolerance to PDC-E2 is pivotal Note: This article points the finger firmly  at acetaminophen (Tylenol or Paracetamol) as a prime cause of PBC! Action Points Primary biliary cholangitis (PBC), a chronic cholestatic liver disease, appears to begin with a loss of immune self-tolerance leading to the destruction of small-…

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Fatigue in primary biliary cirrhosis

Fatigue in primary biliary cirrhosis Matilda Hale, patient1, Julia L Newton, professor of ageing and medicine2, David E J Jones, professor of liver immunology2 Author Affiliations Correspondence to: J L Newton Julia.Newton@newcastle.ac.uk Accepted 4 July 2012 This patient developed severe fatigue as a result of primary biliary cirrhosis in her 40s. She describes her frustration…

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What Is Primary Biliary Cirrhosis?

What Is Primary Biliary Cirrhosis? Primary Biliary Cirrhosis (PBC) is a chronic liver disease that slowly destroys the bile ducts within the liver (intrahepatic bile ducts). Liver inflammation over a period of years may cause scarring which leads to cirrhosis. PBC is NOT alcohol or drug related, and it is NOT contagious. The name “Primary…

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