Posts Tagged ‘fibrosis’

The Advantages and Disadvantages of Liver Fibrosis Evaluation Methods

Chronic liver disease severity is determined by the liver’s landscape; the more liver cells that are damaged and scarred, the more advanced the liver disease is. Even after an initial diagnosis, the current state of your liver’s tissue is a major factor for predicting prognosis and making ongoing therapeutic decisions. Liver biopsy is the globally…

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Now There Are Many (Stages)

Now There Are Many (Stages) Where Before There Was One: In Search of a Pathophysiological Classification of Cirrhosis Guadalupe Garcia-Tsao,1 Scott Friedman,2 John Iredale,3 and Massimo Pinzani4 For more than a century and a half, the description of a liver as “cirrhotic” was sufficient to connote both a pathological and clinical status, and to assign…

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NCKU team discovers new liver disease treatment

NCKU team discovers new liver disease treatment TAIPEI, Taiwan — A National Cheng Kung University (NCKU) team has discovered the pathogenesis of liver fibrosis and developed antibodies that reduce liver damage, inhibit hepatic fibrosis and recover liver function, according to a press release from the school. Ming-shi Chang, chair professor of biochemistry and molecular biology…

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Fast Track Designation for Fatty Liver Disease With Advanced Fibrosis

Fast Track  for Fatty Liver Disease With Advanced Fibrosis Galectin Therapeutics Receives FDA Fast Track Designation for GR-MD-02 for Fatty Liver Disease With Advanced Fibrosis  NORCROSS, Ga., Aug 12, 2013 (GLOBE NEWSWIRE via COMTEX) — Galectin Therapeutics GALT +21.72% , the leading developer of therapeutics that target galectin proteins to treat fibrosis and cancer, today…

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What is Liver Fibrosis?

What is liver fibrosis? Liver fibrosis is the scarring process that represents the liver’s response to injury. In the same way as skin and other organs heal wounds through deposition of collagen and other matrix constituents so the liver repairs injury through the deposition of new collagen. Over time this process can result in cirrhosis…

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Fibrosis Progression to Cirrhosis

Fibrosis and Cirrhosis Cirrhosis is a late stage of hepatic fibrosis that has resulted in widespread distortion of normal hepatic architecture. Cirrhosis is characterized by regenerative nodules surrounded by dense fibrotic tissue. Symptoms may not develop for years and are often nonspecific (eg, anorexia, fatigue, weight loss). Late manifestations include portal hypertension, ascites, and, when…

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Increased Mortality Rates Seen in Chronic Hepatitis C Patients with Pre-Cirrhotic Advanced Fibrosis

Increased Mortality Rates A three-year follow-up study of patients in the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) trial revealed that increased mortality among patients with advanced chronic hepatitis C who received long-term peginterferon therapy was attributed to non-liver related causes and occurred primarily in patients with bridging fibrosis. No pattern to this excess…

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Caffeine Consumption Associated With Less Severe Liver Fibrosis

Caffeine Consumption ScienceDaily (Jan. 6, 2010) — Researchers from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) determined that patients with chronic hepatitis C virus (HCV) who consumed more than 308 mg of caffeine daily had milder liver fibrosis. The daily amount of caffeine intake found to be beneficial is equivalent to…

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Symptoms of Cirrhosis of the Liver

Symptoms of Cirrhosis of the Liver Cirrhosis of the liver refers to a condition characterized by the development of fibrous scar tissue on the liver and regenerative nodules or lumps. This chronic liver disease leads to progressive deterioration of liver function… Liver function is vital to detoxification and protein synthesis, within the human body. It…

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