Primary Biliary Cholangitis
Age, not sex affects UDCA response in patients with PBC
Primary Biliary Cholangitis Older and increasing age among patients with primary biliary cholangitis correlated with a better response to ursodeoxycholic acid treatment and lower rates of liver transplantation and mortality compared with younger age, whereas sex did not affect outcomes, according to a recently published study. “Our data suggests that younger patients should be monitored…
Read More'Deranged liver blood tests' – diagnosing primary biliary cholangitis
‘Deranged liver blood tests’ – diagnosing primary biliary cholangitis 22 October 2018 In the first of a new gastroenterology clinic series, Dr Amine Benmassaoud and Dr Emmanuel Tsochatzis discuss a case of unusual liver bloods Case A 54 year old lady with hypothyroidism on levothyroxine, osteopenia on calcium and vitamin D, and…
Read MoreLong-term obeticholic acid treatment
Long-term obeticholic acid treatment leads to reversal or stabilization of fibrosis/cirrhosis in patients with PBC European Association For The Study Of The Liver 13 April 2018, Paris, France: The first results from the POISE biopsy sub-study have today confirmed that long-term treatment with obeticholic acid (OCA) leads to the reversal or stabilization of fibrosis/cirrhosis in…
Read MoreNew Self-Care App for Primary Biliary Cholangitis (PBC)
New Self-Care App to Support Self-Management for Primary Biliary Cholangitis (PBC) The PBC Health Storylines Mobile App From Self Care Catalysts Was Developed in Collaboration With Patients, and in Partnership With the Canadian PBC Society TORONTO, ON–(Marketwired – September 09, 2016) – To celebrate International PBC Day on September 11, 2016, Self Care Catalysts —…
Read MoreObeticholic acid reduces ALP and bilirubin in primary biliary cholangitis
Obeticholic acid reduced alkaline phosphatase and bilirubin levels in patients with primary biliary cholangitis, according to a phase 3 study published in The New England Journal of Medicine. However, patients taking the drug were more likely to experience pruritis. “The approval of obeticholic acid for primary biliary cholangitis gives us the first new drug for…
Read MoreResults of Phase 3 POISE Trial of Ocaliva® (Obeticholic Acid) for the Treatment of PBC
NEW YORK, Aug. 17, 2016 (GLOBE NEWSWIRE) — Intercept Pharmaceuticals, Inc. (Nasdaq:ICPT), a biopharmaceutical company focused on the development and commercialization of novel therapeutics to treat non-viral, progressive liver diseases, today announced that the New England Journal of Medicine published the key results of the Phase 3 POISE trial of Ocaliva (obeticholic acid) for the treatment…
Read MoreFDA Clears Obeticholic Acid for Primary Biliary Cholangitis
The US Food and Drug Administration (FDA) has granted accelerated approval of obeticholic acid (Ocaliva, Intercept Pharmaceuticals, Inc) for the treatment of primary biliary cholangitis (PBC) in combination with ursodeoxycholic (UDCA) in adults who fail to respond adequately to UDCA, or as monotherapy in adults who cannot tolerate UDCA. Last month, the FDA’s Gastrointestinal Drugs…
Read MoreUDCA fails to improve mortality in primary biliary cholangitis
April 13, 2016 BARCELONA — The use of ursodeoxycholic acid for primary biliary cholangitis failed to reduce all-cause mortality, according to results of a systematic review presented at the International Liver Congress 2016. “Based on current evidence, the treatment of primary biliary cholangitis with ursodeoxycholic acid can neither be supported nor rejected,” Jelena Nincevic, MD,…
Read MoreEnvironmental Factors Tied to PBC – Acetaminophen specifically.
Environmental Factors Tied to PBC Loss of tolerance to PDC-E2 is pivotal Note: This article points the finger firmly at acetaminophen (Tylenol or Paracetamol) as a prime cause of PBC! Action Points Primary biliary cholangitis (PBC), a chronic cholestatic liver disease, appears to begin with a loss of immune self-tolerance leading to the destruction of small-…
Read MoreIs there proof that vaccinations are harmful?
I post this article because I am increasingly concerned at the levels of auto-immune disease that to me anyway, seems to be exploding. Celiac’s Disease, Auto-Immune Hepatitis, Primary Biliary Cholangitis – all on the up. Why? Genetic issues do not account for the increase in these diseases, something else is involved. Some people are pointing the…
Read More